Thursday, May 23, 2013

One more thing that doesn't exist

Here's something else that doesn't exist: an Alzheimer's plaque busting drug.

U.S. scientists say a dramatic result last year suggesting that a cancer drug already approved by U.S. regulators could quickly clear out Alzheimer's plaques in mice was too good to be true.
The study, published last year in the journal Science, showed the skin cancer drug bexarotene cut the amount of an Alzheimer's-linked protein called beta amyloid by half in three days. It also reversed Alzheimer's symptoms, restoring a sense of smell in treated mice and allowing them to resume nest building activities.
The news sent patients clamoring for the drug, and some doctors began prescribing it, even though it had not been tested in people with Alzheimer's. But researchers at several U.S. centers reported in the same journal on Thursday that they were unable to reproduce the most dramatic aspects of the findings in their own labs.
Gary Landreth and colleagues at Case Western Reserve University in Cleveland, the scientists behind the original research, say the drug still has merit, noting that the latest studies confirmed other aspects of the research showing the drug cleared out soluble forms of beta amyloid from the brain.
Scientists say the controversy is a stark reminder of the need for studies to be replicated by other labs, and it underscores the desperation of Alzheimer's sufferers to find effective treatments for the fatal, brain-wasting disease that affects 5 million Americans and 38 million people worldwide.
Sigh.
 Researchers failed to see any effects on Alzheimer's plaques in three strains of mice that were treated with bexarotene.
"There is absolutely no reduction in amyloid levels in the brains of mice treated with this compound," said Sisodia of his group's efforts, which were published as a technical comment in the journal Science. Teams at the University of Florida and researchers at the University of Leuven in Belgium published similar findings in the same journal.
Landreth doesn't accept these results, claiming that they look at the wrong kind of plaque. Probably not coincidentally, he founded a company to study the anti-Alzheimer's effect of the drug.
 Landreth, who has formed a company to study the compound, says the teams are all focusing on the dramatic changes in solid forms of beta amyloid reported in the study, which, despite the press it got, was not the study's main finding.
"We concluded that plaques didn't matter and said so explicitly. As we look at the comments we just don't get it," he said. Landreth can't fully explain why the teams were unable to confirm the findings on plaque.
Even so, he said the latest studies do confirm some of his main findings which suggest the treatment significantly reduces the amount of soluble forms of beta amyloid that float in interstitial fluid that bathes brain cells.
Some studies have suggested that this soluble form of beta amyloid is the more toxic form of the protein, and removing it could offer significant benefits to patients.
A fourth study by a team at the University of Pittsburgh appears to back up his assertion.
The team was able to verify that the drug bexarotene significantly improves cognitive deficits in mice with gene mutations linked to human Alzheimer's. And it confirmed that the compound decreased small bits of toxic beta amyloid in the fluid that surrounds brain cells. But it, too, failed to show a reduction in amyloid plaques.
"We believe these findings make a solid case for continued exploration of bexarotene as a therapeutic treatment for Alzheimer's disease," Dr. Rada Koldamova, who led the study, also published in Science, said in a statement.
Landreth says the current "scientific tempest in a teapot" does not deter his plans to study bexarotene in people.

 

We're not in Kansas anymore

I usually resist comparison games like: who's worse---Hitler or Stalin? But I am tempted to play it with Coburn and Inhofe.

Wednesday, May 22, 2013

We're not in Dorothy Gale's Kansas anymore

I grew up, as many did, with  the tornado in the Wizard of Oz seared into memory. As a child, I came to understand that on the aproach of a tornado, you ran inside a storm cellar, a hole in the ground dug out for the specific purpose of protection from the wind. It is natural, then, that many of us watching the tornado devastation in Moore this week wondered why more homes and the schools did not have storm cellars. The New York Times looks into this:

The Web site for the City of Moore, Okla., recommends “that every residence have a storm safe room or an underground cellar.” It says below-ground shelters are the best protection against tornadoes.
But no local ordinance or building code requires such shelters, either in houses, schools or businesses, and only about 10 percent of homes in Moore have them.
Nor does the rest of Oklahoma, one of the states in the storm belt called Tornado Alley, require them — despite the annual onslaught of deadly and destructive twisters like the one on Monday, which killed at least 24 people, injured hundreds and eliminated entire neighborhoods.

The lack of basements can be explained by the geology of Oklahoma and other tornado alley states, as Megan Garber explains. 
 The relative dearth of storm cellars in Oklahoma may be partially attributed, as things so often can, to environmental factors. The soil in the state is composed largely of clay -- and that's particularly true in central Oklahoma, where Moore is located. ("Soils in the Central Rolling Red Prairies," geologists at Oklahoma State put it (pdf), "are dark and loamy with clayey to loamy subsoils developed on Permian shales, mudstones, sandstones and/or alluvial deposits under tall grasses.") 
The ground in central Oklahoma tends to be soft and moist -- right down to the bedrock that sits, generally, some 20 to 100 feet below the surface.
 Here's the problem with that when it comes to building basements and underground shelters: Clay is particularly fickle as a foundation for construction. When loamy soils absorb rainwater, they expand. And when the weather's dry, they contract. This inevitable and yet largely unpredictable variability makes basement-building a particular challenge, since it makes it nearly impossible to establish firm foundations for underground construction.
And while above-ground homes can be built on these somewhat shaky foundations, adding the element of open space in the form of a basement is a nearly impossible feat of engineering. There is a chance your house, its basement surrounded by glorified mud, will eventually simply topple into itself.
But this explains why structures don't have full basements, not the 21st century version of the Gale family storm cellar. Nor does it explain the absence of community shelters or shelters in schools. The NY Times takes this on.
In Moore, the Web site explains that the city has no community shelter because a 15-minute warning is not enough time to get to safety and because, “overall, people face less risk by taking shelter in a reasonably well-constructed residence.”
This is generally true, but not for a storm like Monday’s milewide tornado, which was a terrible reminder of a tornado that caused extensive damage on May 3, 1999.
Curtis McCarty, a member of the Oklahoma Uniform Building Code Commission and a builder himself, said the twister on Monday would have defeated attempts to resist it above ground. “You cannot build a structure that’s going to take a direct hit from a tornado like that that’s going to stand,” he said.
...................
Construction standards in Moore have been studied extensively. In a 2002 study published in the journal of the American Meteorological Society, Timothy P. Marshal, an engineer in Dallas, suggested that “the quality of new home construction generally was no better than homes built prior to the tornado” in 1999.
Few homes built in the town after the storm were secured to their foundations with bolted plates, which greatly increase resistance to storms; instead, most were secured with the same kinds of nails and pins that failed in 1999. Just 6 of 40 new homes had closet-size safe rooms.
Mayor Glenn Lewis of Moore said that since then, the town had strengthened building codes, including a requirement that new homes incorporate hurricane braces. The city has also aggressively promoted the construction of safe rooms and other measures, with more than $12 million from state and federal emergency management funds to subsidize safe-room construction by offering a $2,000 rebate, said Albert Ashwood, the director of the Oklahoma Department of Emergency Management. Still, he said, it has been several years since Moore has received new financing for the program.
......................

Mike Gilles, a former president of the Oklahoma State Home Builders Association, said that he built safe rooms in all his custom homes, and that even many builders who build speculatively now make them standard.
But asked whether the government should require safe rooms in homes, he said, “Most homebuilders would be against that because we think the market ought to drive what people are putting in the houses, not the government.”
Mr. Anselm, the official in Joplin, said that the city had applied to Missouri for emergency funds for safe rooms, but that the state used money from the Federal Emergency Management Agency primarily for disaster relief from flooding. [my bolding]
Lack of money, diversion of public funds, building code resistance, learned helplessness and magical thinking: besides geology, these explain the absence of storm shelters.

Tuesday, May 21, 2013

Rawlsian nightmares

I'm keeping myself busy not finishing my grades and not watching the new Star Trek idiocy by reading some of my favorite blogs. Feminist Philosophers posted this you tube video on wealth inequality that should be required viewing. Even if you are not avoiding work, it is worth the 6 minutes of your time to watch. It is also worth the time for the 1% to watch  before the tumbrels start rolling.



Star Trek Into Idiocy

I am an old Star Trek fan, but after being alternately puzzled and bored by the first Star Trek reboot in 2009, (and mind you, I sat through Star Trek 5) I was reluctant to subject myself to this year's offering. i09's Spoiler FAQ (and yes, the title indicates the content: spoilers) makes me even more certain that I will avoid it like the IQ lowering, intelligence insulting, mindless piece of shit it looks to be.


Monday, May 20, 2013

San Onofre restart TBD

The NRC has pushed back a decision date for the restart of Unit 2 at San Onofre.
Federal regulators have indefinitely delayed a decision on the proposed restart of the shuttered San Onofre nuclear power plant in California, raising new questions Monday about whether the twin reactors will produce electricity again.
The seaside plant between San Diego and Los Angeles has been dark since January 2012, after a small radiation leak led to the discovery of unusual damage to hundreds of tubes that carry radioactive water.
Operator Southern California Edison wants permission to restart the Unit 2 reactor and run it at reduced power in hopes of stopping vibration and friction that was blamed for damaging tubing.
The Nuclear Regulatory Commission delayed several earlier target dates for a ruling, with officials recently projecting a June announcement. But its website on Monday listed no date for a restart decision — only "to be determined."
.................
 Last month, SCE's parent, Edison International, raised the possibility of retiring the plant if it can't get one reactor running later this year. The company also disclosed that costs tied to the long-running shutdown had hit $553 million.
Edison is facing a tangle of regulatory obstacles that include a separate state investigation into who should pay for the trouble — customers or shareholders.
If I were a betting person, I would put my money on customers.

GOP nominee in Virginia wants to police vaginas

Digby files a report from the not-so-fictional republic of Gilead, which seems to be constituting itself in Virginia, whose GOP just nominated for attonrney general a man who was recently pushing for a bill to criminalize failure to report a miscarriage:
Like a lot of reproductive rights advocates, I've often been accused of being hysterical about the anti-abortion right's agenda. I'm often told that there is no desire to deny women their agency and that we really should lighten up. When we point out that the logical end point of the anti-abortion zealots' arguments for conferring "personhood" from the moment of conception is to criminalize miscarriage, we're told that we are being ridiculous and that we need to calm down.

Not so ridiculous:

If a woman in Virginia has a miscarriage, they must report it within 24 hours to the police or risk going to jail for a full year. At least, that’s what would have happened if a bill introduced by Virginia state Sen. Mark Obenshain (R) had become law.
And yet, the Virginia Republican Party wants to make Obenshain into the state’s top prosecutor. This weekend, Virginia Republicans selected Obenshain as their nominee to replace tea party stalwart Ken Cuccinelli (R) as the state’s attorney general.
She notes that it looks as if existing Virginia statutes already treat miscarriage as a potential crime (and presumably the bathroom the crime scene):
 Meanwhile, did you know that this is already on the books in Virginia?

Even without Obenshain’s bill, Virginia law already treats many miscarriages as potential crimes. Under existing Virginia law, “[w]hen a fetal death occurs without medical attendance upon the mother at or after the delivery or abortion or when inquiry or investigation by a medical examiner is required, the medical examiner shall investigate the cause of fetal death and shall complete and sign the medical certification portion of the fetal death report within twenty-four hours after being notified of a fetal death.”
So, women of Virginia, to stay on the safe side of the law, you might consider notifying the local authorities each time you have a period, since each one might be the result of an early miscarriage.* To be even safer, save your bloody pads and mail them to Obenshain each month, so he can determine whether an investigation is warranted. 

*There was in fact state scrutiny of miscarriages and menstrual periods in Ceausescu's Romania.

Feed your head

Music for grading: