Lateralization of brain connections appears to be a local rather than global property of brain networks, and our data are not consistent with a whole-brain phenotype of greater “left-brained” or greater “right-brained” network strength across individuals. Small increases in lateralization with age were seen, but no differences in gender were observed.............
In popular reports, “left-brained” and “right-brained” have become terms associated with both personality traits and cognitive strategies, with a “left-brained” individual or cognitive style typically associated with a logical, methodical approach and “right-brained” with a more creative, fluid, and intuitive approach. Based on the brain regions we identified as hubs in the broader left-dominant and right-dominant connectivity networks, a more consistent schema might include left-dominant connections associated with language and perception of internal stimuli, and right-dominant connections associated with attention to external stimuli.
Yet our analyses suggest that an individual brain is not “left-brained” or “right-brained” as a global property, but that asymmetric lateralization is a property of individual nodes or local subnetworks, and that different aspects of the left-dominant network and right-dominant network may show relatively greater or lesser lateralization within an individual. If a connection involving one of the left hubs is strongly left-lateralized in an individual, then other connections in the left-dominant network also involving this hub may also be more strongly left lateralized, but this did not translate to a significantly generalized lateralization of the left-dominant network or right-dominant network. Similarly, if a left-dominant network connection was strongly left lateralized, this had no significant effect on the degree of lateralization within connections in the right-dominant network, except for those connections where a left-lateralized connection included a hub that was overlapping or close to a homotopic right-lateralized hub.
The lack of correlation between lateralization and sex goes against some prior studies:
Similarly, we saw no differences in functional lateralization with gender. These results differ from prior studies in which significant gender differences in functional connectivity lateralization were reported , . This may be due to differing methods between the two studies, including the use of short-range connectivity in one of the former reports and correction for structural asymmetries in this report. A prior study performing graph-theoretical analysis of resting state functional connectivity data using a predefined parcellation of the brain also found no significant effects of hemispheric asymmetry with gender, but reported that males tended to be more locally efficient in their right hemispheres and females tended to be more locally efficient in their left hemispheres .