Wednesday, January 29, 2014

Yay science! Stem cell edition

 This is good news.
Scientists in Japan showed stem cells can now be made quickly just by dipping blood cells into acid.
Stem cells can transform into any tissue and are already being trialled for healing the eye, heart and brain.
The latest development, published in the journal Nature, could make the technology cheaper, faster and safer.
It moots the continuing war over the scientific use of human embryos.

Now a study shows that shocking blood cells with acid could also trigger the transformation into stem cells - this time termed STAP (stimulus-triggered acquisition of pluripotency) cells.
Dr Haruko Obokata, from the Riken Centre for Developmental Biology in Japan, said she was "really surprised" that cells could respond to their environment in this way.
Of course, the blood cells being shocked by acid were mouse cells, and we can't assume that this technique will work on human cells. But if it does...
 Chris Mason, professor of regenerative medicine at University College London, said if it also works in humans then "the age of personalised medicine would have finally arrived."
He told the BBC: "I thought - 'my God that's a game changer!' It's a very exciting, but surprise, finding.
"It looks a bit too good to be true, but the number of experts who have reviewed and checked this, I'm sure that it is.
"If this works in people as well as it does in mice, it looks faster, cheaper and possibly safer than other cell reprogramming technologies - personalised reprogrammed cell therapies may now be viable."
For age-related macular degeneration, which causes sight loss, it takes 10 months to go from a patient's skin sample to a therapy that could be injected into their eye -and at huge cost.
Prof Mason said weeks could be knocked off that time which would save money, as would cheaper components.
To be sure, actual therapy for humans is not likely to be around the corner.

The finding has been described as "remarkable" by the Medical Research Council's Prof Robin Lovell-Badge and as "a major scientific discovery" by Dr Dusko Ilic, a reader in stem cell science at Kings College London.
Dr Ilic added: "The approach is indeed revolutionary.
"It will make a fundamental change in how scientists perceive the interplay of environment and genome."
But he added: "It does not bring stem cell-based therapy closer. We will need to use the same precautions for the cells generated in this way as for the cells isolated from embryos or reprogrammed with a standard method."
So does this finding herald the start of personalized regenerative medicine, growing everything from retinas to kidneys from the patient's own cells? Probably not, but it is nice to pretend it does---a warming thought on a cold, cold day.

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